Since more than 100 years, scientists have studied the effects of climate change. Transplantation is a good idea.The kidneys of animals are used to make human kidneys.
They have been unable to function these organs for more than a hundred years.
Researchers at the University of Alabama claim a world first.
With the family’s permission, they successfully transplanted kidneys from an injected pig into a brain dead patient.
Scientists have done this before Some successThe current case study is unique in that the kidneys of the pigs produced urine quickly and cleared the body of the patient. Creinine.
Creatinine, a breakdown of a waste material produced mainly by muscle cells, can only leave our bodies through our kidneys. SoThese are vital measures of kidney health that must be taken to maintain life.
No one has succeeded in Measurements that are reliableBefore and after
When the organs of one species are transplanted into another, it’s known as ‘xenotransplantation’.
In the past, most of these surgeries failed because the immune systems attack the foreign tissue. Scientists could theoretically avoid rejection if the animal organ was genetically modified in a way that fooled the immune system of humans into accepting it.
This proof of principle was now carried out with astounding success in a hospital. Toby Coates – a clinician scientist from the University of Adelaide not involved in the case – said the new xenotransplant has been successful because of a ‘key advancement’ in genetic modifications.
According to him, the removal of 4 pig genes was followed by the introduction of 6 human genes. This helped “prevent bleeding and ‘humanize the kidney of a pig”.
Researchers need to confirm that these human-like kidneys from pigs can be used in humans. Temporary ‘bridges or destination therapies’For those with kidney disease that has reached the end stage.
Either scenario is welcome. In the US, approximately 40 percent of kidney transplant patients die within five years of being on the list.
The United States is home to 25,000 kidney recipients each year. More than 800,000 patientsWith end-stage renal disease.
One successful xenotransplant doesn’t make this solution effective or safe.
A few years back, some of the scientists who did this transplanted two kidneys from an animal with 10 Genetic ModificationsIt didn’t work as well in a brain-dead person who was a different patient. The kidneys were rejected by the patient’s body, not the organs. The message was not clear Did not remove enough creatinine from the blood to lower levels or detectable in the urine, either.
Scientists remain skepticalIt is unlikely that xenotransplants on bread-dead people will result in living patients. Extending these experiments to this group is controversial.
Scientists could start by using kidney xenotransplants, which can be safely removed from the body if an immune rejection occurs.
Advocates for xenotransplantation research You can also read about how to get in touch with us.We should be cautious, but these actions could potentially save lives.
Coates said, “Although it is still in an early stage, this study gives hope to over 15,000 Australians currently on dialysis that could benefit by a kidney donation.” The following is a list of words that begin with the word “you”“…and possibly helps overcome the shortage of human donor kidneys.”
The letter has been published in JAMA Surgery.
