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ScienceAlert: A varied lifestyle boosts brain connectivity in mice

An active and varied lifestyle in mice benefits the brain by creating enhanced neural connections.

Researchers in Germany have compared brain activity between mice raised in different environments. They found that those raised in a ‘enriched environment’ had more activity in the brain. HippocampusThis suggests the presence of an even more robust and interconnected neural network.

The human hippocampus, which plays a central role in memory and learning, is often affected by degenerative diseases of the brain like Alzheimer’s. Alzheimer’s.

Connectome map of’standard mouse’ on left and enriched mouse on right, colored by region. (Emery et al., Biosens. Bioelectron., 2023)

The results exceeded our expectations by a wide margin The following is a list of words that begin with the word “you”Hayder Amin, a biomedical and neuroscientific engineer from the German Center for Neurodegenerative Diseases DZNE said: “Simplified speaking, it can be said that the neurons in mice raised in enriched environments were more interconnected than those of mice raised in standard housing.”

The findings based on Amin & colleagues’ “brains-on-chips” technology, and computational analysis tools could be used to help support and avoid brain dysfunctions, and to develop new brain-inspired technologies. artificial intelligence methods.

We have found a lot of evidence that shows how a brain formed by experience is more effective. The following is a list of words that begin with the word “you”Gerd Kempermann is a DZNE researcher who studies adult neurogenesis.

The scientists compared the brain tissue of two 12-week-old groups of mice, whose lives began at six weeks. The scientists compared brain tissue from two groups of 12-week-old mice whose experiences began at six weeks.

The other group enjoyed themselves in larger cages that included toys, tunnels made of plastic tubes, nesting material and small houses.

The researchers used a microscope to examine brain tissue. complementary metal–oxide–semiconductorA neurochip based on CMOS with 4,096 electrodes to record thousands of neurons simultaneously.

They were able, through their measurements, to determine the level of connectivity between all the hippocampuses and the brain’s outer layer. This outer layer governs many cognition processes. These cognitive processes are grouped together into six hippocampal/cortical areas that are interconnected.

brain activity in mouse tissue
Comparing brain activity as measured by Local Field Potential(DZNE/Amin Lab) in six areas. (DZNE/Amin Lab)

“No matter what parameters we studied, a richer experiences literally boosted the connections in the neural networks,” The following is a list of words that begin with the word “you” Amin. The findings indicate that a life filled with activity and variety can shape the brain in new ways.

Our The mark of experience is left behindThis shows how important these marks can be.

“All that we have known about this subject so far was derived from either studies using single electrodes or imaging methods like Magnetic resonance imagingKempermann The explanation of the explains. “We can literally see the circuitry in action down to the scales of individual cells.”

Large-scale CMOS-based Biosensor Framework
A description of the technology and process involved. (Emery et al., Biosensors & Bioelectronics, 2023)

Amin, Kempermann and the rest hope that their tools can be extended to examine how social interactions and physical activity affect brain function.

The results were not seen in humans but rather mice, and the entire hippocampus gave them a broader view of Functional connectivity.

Scientists believe that MapsUnderstanding how experiences change The connectomeIt could be used to identify new targets and mechanisms for future treatments that are more effective.

The platform they provide could be the foundation for Prosthetic devicesMemory loss due to age or disease can be improved by using products that mimic brain function.

Kempermann: “This opens the door to understanding the role of plasticity in neurodegenerative disease, and the formation of reserves. This is especially important for novel prevention strategies.” The following is a list of words that begin with the word “you”.

This will also help provide insight into disease processes associated to neurodegeneration such as the dysfunction of brain networks.

The study was published in Biosensors & Bioelectronics.

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