Step forward platelet factor 4Three separate studies have linked (PF4), a substance found in the blood, to mental benefits from exercise, blood transfusions and a protein that is associated with long life.
All three processes enhance cognitive function, making PF4 a kind of super-blood factor. Two teams, one from the University of California San Francisco in the US, and another from the University of Queensland Australia, carried out the research.
Platelets are the cell fragments which play a vital role in the Clotting Process. These small, nonnucleated pieces of bone marrow cells contain granules which release chemicals that promote aggregation.
The protein PF4 is one of the factors that contribute to the immune response to infection and injury.
It appears that it also plays a role in antiaging mechanisms, under the guidance of an enzyme known as klotho.
“Young blood and klotho can tell your brain to improve its function,” The following is a list of words that begin with the word “you”Saul Villeda is an anatomist with the UCSF.
“With PF4, I’m starting to get the vocabulary of this rejuvenation.”
In the study of young blood, older mice were injected PF4 which has been shown to reduce Brain inflammationThe animals’ memory is improved. In essence, it reversed the degeneration that occurs with age.
The study builds on prior research into what is Parabiosis is also known asThe blood of younger humans and animals can be rejuvenating. Younger blood is more likely to contain PF4.
The scientists, using mice in the second study, were able, once again, to link PF4 and the membrane-protein klotho. Klotho was Prior to that,PF4 has been shown to enhance cognitive abilities, and it turns our that PF4 transfers that boost to right brain regions.
The behavior of both young and old mice improved after an injection with klotho. This releases PF4. This increased the formation of new neural connections in the HippocampusThis is where the brain stores memories.
The third study, which is not the least important, found that exercise released more PF4 in the blood of mice. The PF4 played a part in the formation of new brain cell and Memory functions improvedOlder mice are more susceptible to disease.
We all know that exercise is good for us. Help to keep your mind sharpIt appears that PF4 has a role to play in this. Future therapies may deliver the benefits from exercise to those who can’t be active normally.
The findings of these mice studies are believed to be applicable to the human body, indicating multiple ways PF4 could help in Future Treatments.
Our jaws dropped when we discovered that we’d independently and by chance found the exact same thing. The following is a list of words that begin with the word “you” UCSF neurologist Dena Dubal.
The fact that three different interventions have converged around platelet factors highlights the validity and repeatability of this biology.
The research was published in Nature, Nature Aging. Nature Communications.
