The experimental vaccine aims to slow or prevent the progression Alzheimer’sThe disease has been tested in mice and the early results are promising.
Following the vaccine, mice with genes that increase their risk for an Alzheimer’s disease-like illness had fewer amyloid deposits.
A team of researchers from Japan’s Juntendo Medical Graduate School found that the patients also showed improved behavior and awareness.
But the findings are still being peer-reviewed. So we shouldn’t get overly excited. They’ve been a lot of work. Just presentedThe American Heart Association is celebrating its Basic Cardiovascular Sciences Scientific Conference 2023Boston is a city that has a lot to offer.
The novel vaccine test we conducted in mice could be a way to modify or prevent the disease. Chieh -Lun Hsiao is one of the researchers who led this project, a cardiovascular biologist.
“If this vaccine proves to be effective in humans, that would be a huge step forward for delaying the disease progression or even preventing it.”
The announcement is made shortly after the aforementioned a Major Trial in humans found a new drug – which may soon be approved by the FDA – can help Slow the disease’s progress by months.
The new potential vaccine targets a protein which appears in Senescent cells – aging cells that have stopped dividing, but instead of being cleared away by the body they hang around and trigger inflammation.
One of the proteins senescent cells express is SAGP, or senescence-associated glycoprotein, and this is the target of the vaccine.
Researchers had Vaccines are being developedTreating a wide range of age related diseases Type 2 diabetesIn mice.
You can also read about it here Other researchers have shownThe SAGP gene is also highly expressed within the neural support tissue (called glial cells) in people with Alzheimer’s disease, so the team decided to test the vaccine in mice genetically engineered to develop a build-up of amyloid plaques and display Alzheimer’s-like symptoms.
You can also find out more about us on our website. Two and four months oldThese mice received either the SAGP or placebo vaccine.
Researchers then examined their brains and bodies after sacrificing them. They tested their behavior on a maze device when they were six months old.
The mice that were vaccinated displayed significant improvement in the behavioral tests. They were more aware of their environment and behaved like normal mice. According to a press releaseDetailing your findings
In addition, there are several biomarkers for inflammation. ReducedThey are able to do this because of their brains.
Mice that had been vaccinated have also developed a weakened immune system. Significantly reducedThe buildup of plaques amyloid in the cerebral cortex – a region of the brain linked to language processing and problem solving.
Researchers found that SAGP protein was a significant factor in the development of autoimmune diseases. Highly expressedNearly specialized brain cells are called microglia. The immune system of the central nervous is heavily reliant on microglia.
But microglia can also trigger inflammation – and it’s Already being suspectedThey play a part in Alzheimer’s.
The results of the trial suggest that microglia can be used to treat this disease.
By removing microglia in an activation state in the brain, inflammation may be controlled.” Hsiao.
“A vaccine would target activated Microglia, and remove these harmful cells. This would ultimately repair the deficits of behavior that are suffered by Alzheimer’s.”
You can also find out more about this by clicking here. This isn’t my first attempt at making an Alzheimer’s vaccine – there are even Other possible vaccinesYou can also read about it here Being tested on humans.
After these findings are published there is a long way to travel before a therapy such as this can be tested on humans.
It’s encouraging that the vaccine is linked to behavioral improvement, which shows we may be onto something.
The results of earlier studies on mice models that used different vaccines for treating Alzheimer’s disease were successful in reducing the amyloid deposits and inflammation factors.” Hsiao.
Our study is different because our SAGP vaccination also changed the behavior in these mice.
The abstracts presented at the American Heart Association Basic Cardiovascular Sciences Scientific Sessions in 2023 can be read here. Here is a link to the article.
